Trip to PKUK 2016
It was dominated by PBPK modelling presentations, including an extremely complex model for dermal absorption by Nikunjkumar Patel, Simcyp.
A nice alternative perspective was given by Hitesh Mistry, University of Manchester, who was discussing the risks of using extremely complicated systems pharmacology models, where parameters are often based on experiments that cannot be reproduced, as exemplified by how an extremely simple model could predict QT prolongation better than full heart models. Check presentation here: https://figshare.com/articles/A_simple_model_for_ion-channel_related_cardiac_toxicity_pptx/3829914 and blog here: http://systemsforecasting.com/2016/07/mathematical-models-for-ion-channel-cardiac-toxicity-david-v-goliath/
Joel Tarning, Centre for Tropical Medicine and Global Health, Nuffield department of Medicine, Mahodil University, Bangkok, gave a very nice presentation of modelling of both endpoint and parasite count data in malaria.
Stefano Zamuner, GSK, presented some interesting immunology models. He also referred to clinical trial simulation in his presentation.
Yasunori Aoki gave an excellent presentation about popED lite, a simple to use optimisation tool mainly focussing on the preclinical area. It has no population aspect in the optimisation, but is so easy to use that I can definitely see myself trying it as a first step, or as a sanity check. On mac app store, or download here for pc: http://www.bluetree.me/PopED_lite.html
Graham Wheeler, MRC BSU/UCL gave a good talk on the use of adaptive designs for first-in-man studies in oncology, e.g. using the Bayesian methods.
Andy Hooker, Uppsala University, spoke about how to use model based optimal design in adaptive studies.
Fenando Ortega, Manchester, gave a nice presentation about finding a simple mechanistic model for Abeta amyloid accumulation in mice.
Dagan Lonsdale, a physician at St Georges hospital London, presented some very early results on Antibiotics in adult and paediatric intensive care patients. The ambitious scope of what they are trying to do is exciting, and he was a wonderful presenter.
The full programme and abstract booklet can be found on http://www.pkuk.org.uk/