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The Simulo Expert library: an overview

Of course, you can develop any model you want in Simulo. This is typically the first exercise in the training: implement a standard, publicly available model into Simulo.

To give you a taste of what is possible with Simulo, the Expert version is delivered with a wide variety of demonstration models:

Scientific demonstration models

Integrated Glucose Insulin Model

The integrated glucose-insulin model was adapted from Modeling of 24-Hour Glucose and Insulin Profiles of Patients With Type 2 Diabetes - Petra M. Jauslin, Nicolas Frey and Mats O. Karlsson - J Clin Pharmacol (2011) 51:  153-64. The model combines both glucose and insulin models, while keeping a clear overview.

IGI model structure
Structural model

Glucose results

Insulin results

Parkinson Disease

Parkinson Disease model

Based on the model, we can simulate change from baseline for Placebo and Treatment.

Results for PD model

Viral Kinetic Model

Viral Kinetic Model results

Viral Kinetic Model results

Standard demo library

For teaching purposes, it may be interesting to direct students straight to an already-implemented model. These models have also been used to test and validate Simulo, comparing the output to other simulation tools on the market.

Library Model types Description
PK Library 1‑compartment (18 models) PK single compartment models: with/without saturation in elimination, administration by bolus, infusion or oral absorption, with/without lag time
2‑compartment (18 models) PK 2‑compartment models: with/without saturation in elimination, administration by bolus, infusion or oral absorption, with/without lag time
3‑compartments (18 models) PK 3‑compartment models: with/without saturation in elimination, administration by bolus, infusion or oral absorption, with/without lag time
PD Library 1‑compartment (27 models) On basis of a basic single compartment model with oral administration, a PD library with all kinds of direct effects: no, constant baseline or linear/exp/dexp time-dependent term; linear, logarithmic or quadratic effect of concentration; EMAX or IMAX with/without GAMMA exponent
Indirect-response Library 1‑compartment & oral absorption based (4 models) On basis of a basic single compartment model with oral administration, 4 indirect response models: Inhibition of build-up, Inhibition of loss, Stimulation of build-up & Stimulation of loss
Count Data Library Count data (4 models) Negative Binomial, Poisson, Zero-Inflated Negative Binomial, Zero-Inflated Poisson regression models

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