The Simulo Expert library: an overview
Of course, you can develop any model you want in Simulo. This is typically the first exercise in the training: implement a standard, publicly available model into Simulo.
To give you a taste of what is possible with Simulo, the Expert version is delivered with a wide variety of demonstration models:
- Integrated Glucose-Insulin Model
- Parkinson Disease
- And typical standard models, provided as demo files
Scientific demonstration models
Integrated Glucose Insulin Model
The integrated glucose-insulin model was adapted from Modeling of 24-Hour Glucose and Insulin Profiles of Patients With Type 2 Diabetes - Petra M. Jauslin, Nicolas Frey and Mats O. Karlsson - J Clin Pharmacol (2011) 51: 153-64. The model combines both glucose and insulin models, while keeping a clear overview.
The model was implemented based on Washout and delayed start designs for identifying disease modifying effects in slowly progressive diseases using disease progression analysis, Berend Arnold Ploeger and Nicholas H. G. Holford.
Based on the model, we can simulate change from baseline for Placebo and Treatment.
Viral Kinetic Model
This model was based on The use of the SAEM algorithm in MONOLIX software for estimation of population pharmacokinetic pharmacodynamic-viral dynamics parameters of maraviroc in asymptomatic HIV subjects, Phylinda L. S. Chan, Philippe Jacqmin, Marc Lavielle, Lynn McFadyen and Barry Weatherley.
Standard demo library
For teaching purposes, it may be interesting to direct students straight to an already-implemented model. These models have also been used to test and validate Simulo, comparing the output to other simulation tools on the market.
|PK Library||1‑compartment (18 models)||PK single compartment models: with/without saturation in elimination, administration by bolus, infusion or oral absorption, with/without lag time|
|2‑compartment (18 models)||PK 2‑compartment models: with/without saturation in elimination, administration by bolus, infusion or oral absorption, with/without lag time|
|3‑compartments (18 models)||PK 3‑compartment models: with/without saturation in elimination, administration by bolus, infusion or oral absorption, with/without lag time|
|PD Library||1‑compartment (27 models)||On basis of a basic single compartment model with oral administration, a PD library with all kinds of direct effects: no, constant baseline or linear/exp/dexp time-dependent term; linear, logarithmic or quadratic effect of concentration; EMAX or IMAX with/without GAMMA exponent|
|Indirect-response Library||1‑compartment & oral absorption based (4 models)||On basis of a basic single compartment model with oral administration, 4 indirect response models: Inhibition of build-up, Inhibition of loss, Stimulation of build-up & Stimulation of loss|
|Count Data Library||Count data (4 models)||Negative Binomial, Poisson, Zero-Inflated Negative Binomial, Zero-Inflated Poisson regression models|